Our research laboratory is interested in exploring novel strategies that apply stimuli-responsive systems for delivering therapeutics in dose-, spatial- and temporal-controlled fashions. By accumulating and integrating tools of biomolecular engineering, materials chemistry and micro/nano fabrication, we are adapting the concept of “artificial vesicles”, which are inspired by effective approaches found in natural particulates, from viruses to cells. Drug delivery through such vehicles can be specifically regulated by physiological signals, such as glucose, ATP and reactive oxygen species, the level or activity of which is often closely associated with many diseases, including diabetes and cancer. In particular, we are studying glucose-responsive synthetic formulations and devices for delivering insulin in a self-regulated manner, which mimics the function of pancreatic β-cells. We are also developing the “programmed” anticancer drug delivery systems that can respond upon the elements within tumor microenvironment or subcellular environment and sequentially release multiple drugs to their most active destinations. In addition to endogenous triggers, we are also interested in utilizing exogenous triggers, such as ultrasound and light to achieve spatiotemporal administration.
Key Words: Bioresponsive Materials/Formulations; Cell Therapy; Smart Insulin Delivery; Delivery of Immune Therapeutics; Bioinspired/Biomimetic Design
Featured Inventions: Bioresponsive Microneedle Patches (Smart Insulin Patch; Browning Patch; Melanin Patch; Blood Thinner Patch; Cell Patch); Platelet-Mediated Checkpoint Blockade; Platelet-Mimicking Nanomedicine; Liquid-Metal Nanomedicine; DNA Nanoclews; Elastic Drug Delivery
Project 1: Glucose-Responsive Closed-Loop Insulin Delivery (ACS Nano, 2018; Nature Chemical Biology, 2017; Nature Chemistry, 2017; PNAS, 2015; Advanced Materials, 2016; Nano Letters, 2017; ACS Nano, 2017; Biomacromolecules, 2014; ACS Nano, 2013; ACS Nano, 2013;Chemical Society Reviews, 2014)
Project 2: Local/Targeted Delivery of Immunomodulators (e.g., Immune Checkpoint Inhibitors)(Science Translational Medicine, 2018; Science Immunology, 2017; Nature Biomedical Engineering, 2017; Nano Letters, 2016; ACS Nano, 2016)
Project 3: Tumor Microenvironment/ Subcellular Environment-Triggered Programmable Delivery of Anticancer Drugs or Genome Editing Tools (Nature Biomedical Engineering, 2018; Nature Communications, 2014; Nature Communications, 2015; Nature Reviews Materials, 2016; Advanced Materials, 2014; Advanced Materials, 2015; Advanced Materials, 2016; JACS, 2015; Angewandte Chemie, 2014; Biomaterials, 2015; Physiological Reviews, 2016)
Project 4: Mechanical Force-Mediated Controlled Drug Delivery (Chemical Reviews, 2016; ACS Nano, 2015; Advanced Healthcare Materials, 2014; Journal of Controlled Release, 2015)